Influence of implant surface coated with Ph buffering agent on early osseointegration
By: Joo Hyun Kang, Su-Kyoung Kim, Hyung Chul Pae, jin Young Park, Jae-Kook Cha, Seong-Ho Choi
Purpose
Surface treatment with pH buffering agent has been developed to achieve higher and faster osseointegration.
The aim of this study was to evaluate its influence by measuring removal torque and analyzing histological characteristics.
Materials & Methods
Subjects and Outcomes of the study
Subject : Nine adult male miniature pigs aged 1 to 2 years and weighing 45 to 55 kg were used, three pigs for removal torque test and six pigs for histological evaluation.
Implants : Titanium implants with following surfaces were used in this study:
1) sand-blasted acid-etched(SA) surface (SA group as control 1 group)
2) SA surface in calcium chloride aqueous solution (CA group as control 2 group)
3) SA surface coated with pH buffering agent (pH group as test group).
Removal torque test after 2 weeks and bone-to-implant contact and bone area analyses at 2 and 4 weeks were performed.
Results
The rotational torque values at 2 weeks were significantly higher in pH group (107.5 6.2 Ncm, P<0.05)
The mean values of bone-to-implant contact at 2 and 4 weeks were both higher in pH group (93.0% 6.4%
at 2 weeks, 88.6% 5.5% at 4 weeks) than in SA group (49.7% 9.7% at 2 weeks, 47.3% 20.1% at
4weeks) and CA group (73.7% 12.4% at 2 weeks, 72.5% 10.9% at 4 weeks) with significances(P<0.05).
The means of bone area showed significantly higher numbers in pH group(39.5% 11.3% at 2 weeks,
71.9% 10.9% at 4 weeks, P<0.05)
Conclusion
Surface modification with pH buffering agent improved early osseointegration with superior biomechanical property.
Fig 1. Removal torque values (Ncm) after 2 weeks healing period. *Significantly different from conventional sand-blasted acid etched (SA) surface (P<0.05). Significantly different from SA surface in calcium chloride aqueous solution (CA) (P<0.05).
Fig 2. Representative histological sections per group at 4 weeks healing time. The bony tissue lo cated between second, third and fourth threads of implant was included in the assessments. (A) Conventional sand-blasted acid etched surface (SA) group, (B) SA surface in calcium chloride aqueous solution (CA) group, (C) pH group.
Fig 2. Representative histological sections per group at 4 weeks healing time. The bony tissue lo cated between second, third and fourth threads of implant was included in the assessments. (A) Conventional sand-blasted acid etched surface (SA) group, (B) SA surface in calcium chloride aqueous solution (CA) group, (C) pH group.
Fig 3. Bone-to-implant contact (%) after 2 and 4 weeks of healing periods. *Significantly different from conventional sand-blasted acid etched (SA) surface (P<0.05). Significantly different from SA surface in calcium chloride aqueous solution (CA) (P<0.05).
Fig 4. Bone area (%) after 2 and 4 weeks of healing periods. *Significantly different from conventional sand-blasted acid etched (SA) surface
(P<0.05). Significantly different from SA surface in calcium chloride aqueous solution (CA) (P<0.05).
